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KMID : 0387820070140020198
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Clinical Pediatric Hematology-Oncology
2007 Volume.14 No. 2 p.198 ~ p.201
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A Case of Intractable Gastrointestinal Bleeding during Chemotherapy in Hereditary Coagulation Factor Deficiency
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Lee Ji-Hye
Lee Kun-Soo
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Abstract
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A congenital factor VII deficiency is a rare bleeding disorder and autosomal recessively inherited. Its clinical manifestations are variable from asymptomatic to life threatening bleeding. Chemotherapy can cause a hemorrhagic event due to tissue (mucosa) damage, multiple coagulation factor deficiency and thrombocytopenia. So the patient who has a cancer with congenital factor VII deficiency has a higher risk of bleeding during chemotherapy. We report a congenital factor VII deficient 11-year-old boy who was diagnosed as Ewing sarcoma and treated with multiple chemotherapeutic agents. The patient died of the chemotherapy 46 days due to intractable gastrointestinal bleeding despite the use of recombinant activated factor VII replacement and transfusion of fresh frozen plasma and platelet concentrates.
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KEYWORD
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Congenital factor VII deficiency, Gastrointestinal bleeding, Chemotherapy, Recombinant activated factor VII
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